regmedjournalРегенерация органов и тканейРегенерация органов и тканей2949-5938Общество регенеративной медицины10.60043/2949-5938-2026-3-7-18regmedjournal-157Research ArticleОБЗОРЫ И КОММЕНТАРИИREVIEWS AND COMMENTSРегуляция клеточной пластичности — историческое развитие научных представленийRegulation of cellular plasticity: A historical development of scientific conceptВоротелякЕ. А.VorotelyakE. A.

Воротеляк Екатерина Андреевна — член-корреспондент РАН, д.б.н., заведующий лабораторией клеточной биологии; заведующий кафедрой клеточной биологии и гистологии

119334, г. Москва, ул. Вавилова, д. 26;

119234, г. Москва, Ленинские горы, д. 1, стр. 12

Ekaterina A. Vorotelyak — Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Biology), Head of the Laboratory of Cell Biology; Head of the Department of Cell Biology and Histology, Faculty of Biology

119334, Vavilov str., 26;  119234, Leninskie Gory, 1/12

vorotelyak@yandex.ruФГБУН «Институт биологии развития им. Н.К. Кольцова» РАН; ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияKoltzov Institute of Developmental Biology of Russian Academy of Sciences; Lomonosov Moscow State UniversityRussian Federation20261410202643718Copyright © Воротеляк Е.А., 20262026Воротеляк Е.А.Vorotelyak E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.regmed-journal.ru/jour/article/view/157

В современной клеточной биологии с  понятием пластичности связано значительное количество работ, включающих исследования плюрипотентного статуса, механизмов регенерации и  онкогенеза, биотехнологических приложений, математических моделей клеточной дифференцировки, биоинформатического анализа траекторий развития и дифференцировки и многое другое. По каждой из этих областей можно найти обширную литературу, в том числе обзоры. Полное рассмотрение всех деталей и аспектов развития теории клеточной пластичности может быть предметом отдельного обширного исследования. Цель данного обзора — кратко обозначить главные вехи эволюции концепций клеточной пластичности от классической детерминистской парадигмы до современных воззрений в  русле динамических систем, эпигенетических ландшафтов и аттракторов. Рассматриваются ключевые открытия и их значение для развития представлений о клеточной пластичности.

In modern cell biology, the concept of plasticity is associated with a vast body of work, including studies on pluripotent status, mechanisms of regeneration and oncogenesis, biotechnological applications, mathematical models of cell differentiation, bioinformatic analysis of developmental and differentiation trajectories, and much more. There is extensive literature available on each of these areas, including reviews. A comprehensive examination of all the details and aspects of the development of the theory of cellular plasticity would require a separate extensive study. The purpose of this review is to briefly outline the main milestones in the evolution of the concept of cellular plasticity, from the classical deterministic paradigm to modern views based on dynamic systems, epigenetic landscapes, and attractors. Key discoveries and their significance for the development of the concept of cellular plasticity are discussed.

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The authors declare that there are no conflicts of interest present.