regmedjournalРегенерация органов и тканейРегенерация органов и тканей2949-5938Общество регенеративной медицины10.60043/2949-5938-2023-2-33-54regmedjournal-35Research ArticleОБЗОРЫ И КОММЕНТАРИИREVIEWS AND COMMENTSВозможности биотехнологической платформы тутового шелкопряда (B. mori) для регенеративной медициныPossibilities of Bombyx mori (B. mori) biotechnological platform for regenerative medicineЮматовЕ. Н.YumatovE. N.

Юматов Евгений Николаевич  — индивидуальный предприниматель, научный сотрудник Научно-исследовательской станции шелководства 

Ставропольский край, г. Железноводск

Evgeniy N. Yumatov — individual entrepreneur, researcher 

Stavropol Region, Zheleznovodsk

trast1207@mail.ruЕвлагинаЕ. Г.EvlaginaE. G.

Евлагина Елена Григорьевна — директор Научно-исследовательской станции шелководства

Ставропольский край, г. Железноводск

Elena G. Evlagina — director of the RS of Sericulture

Stavropol Region, Zheleznovodsk

ЕвлагинВ. Г.EvlaginV. G.

Евлагин Виктор Григорьевич — научный сотрудник Научно-исследовательской станции шелководства

Ставропольский край, г. Железноводск

Viktor G. Evlagin — researcher Research Station of Sericulture

Stavropol Region, Zheleznovodsk

ЛейнвеберЕ. Ф.LeinweberE. F.

Лейнвебер Евдокия Федотовна  — кандидат сельскохозяйственных наук, старший научный сотрудник Научно-исследовательской станции шелководства

Ставропольский край, г. Железноводск

Evdokia F. Leinweber  — Ph.D. of Agricultural Sciences, senior researcher Research Station of Sericulture

Stavropol Region, Zheleznovodsk

ТовпекоД. В.TovpekoD. V.

 Товпеко Дмитрий Викторович  — младший научный сотрудник научно-исследовательской лаборатории (военной терапии) научно-исследовательского отдела (экспериментальной медицины) научно-исследовательского центра

г. Санкт-Петербург

Dmitry V. Tovpeko  — junior researcher of the Research Laboratory of military therapy

St. Petersburg,

ДебенокС. С.DebenokS. S.

 Дебенок Семён Сергеевич  — старший лаборант научно-исследовательской лаборатории (тканевой инженерии) научно-исследовательского отдела (медико-биологических исследований) научно-исследовательского центра

г. Санкт-Петербург

Semyon S. Debenok — senior laboratory assistant of Research Laboratory of tissue engineering 

St. Petersburg

Индивидуальный предприниматель Юматов Е.Н.; Научно-исследовательская станция шелководства — филиал ФГБНУ «Северо-Кавказский федеральный научный аграрный центр»РоссияIndividual entrepreneur; Sericulture Research Station — branch of the North Caucasus Federal Scientific Agrarian CenterRussian FederationНаучно-исследовательская станция шелководства — филиал ФГБНУ «Северо-Кавказский федеральный научный аграрный центр»РоссияSericulture Research Station — branch of the North Caucasus Federal Scientific Agrarian CenterRussian FederationФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова»РоссияResearch Department (medical and biological research) of the Research Center of the Military Medical Academy named after S.M. KirovRussian Federation202302072024123354Copyright © Юматов Е.Н., Евлагина Е.Г., Евлагин В.Г., Лейнвебер Е.Ф., Товпеко Д.В., Дебенок С.С., 20242024Юматов Е.Н., Евлагина Е.Г., Евлагин В.Г., Лейнвебер Е.Ф., Товпеко Д.В., Дебенок С.С.Yumatov E.N., Evlagina E.G., Evlagin V.G., Leinweber E.F., Tovpeko D.V., Debenok S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.regmed-journal.ru/jour/article/view/35

Регенеративная медицина, стремящаяся изменить современную медицинскую практику путем устранения коренных причин болезней и  расстройств, включает генную терапию, клеточную терапию и продукты тканевой инженерии, предназначенные для увеличения, восстановления, замены или регенерации органов, тканей, клеток, генов и метаболических процессов в организме. Биоматериалы — один из ключевых компонентов регенеративной медицины, на которых базируются успешные стратегии.

Представлен обзор биотехнологических методов, применяемых на этапах восходящего (USP) и нисходящего (DSP) процессов с использованием тутового шелкопряда (B. mori), направленных на улучшение качественных характеристик и  получение новых видов биоматериалов для удовлетворения потребностей регенеративной медицины и биомедицины. Разнообразие биотехнологических решений, позволяющих получить широкий спектр биоматериалов: производные оболочки кокона  — фиброин, серицин и  их композиты, рекомбинантные производные, антимикробные пептиды, модифицированные трансгенные шелковые волокна, трансгенные волокна, содержащие факторы роста и пептиды и др., — в совокупности представляет уникальный базис для создания биоиндустриальной платформы на основе тутового шелкопряда.

Regenerative medicine aims at changing modern medicine practice by eliminating core reasons of diseases and disorders. Regenerative medicine includes gene therapy, cell therapy and products of tissue engineering that are destined for augmentation, regeneration or replacement of organs, tissues, genes and metabolic processes in the organism. Biomaterials are amongst key components of regenerative medicine on which successful strategies are based.

The review of biotechnological methods implemented in the USP and DSP stages with the use of B. mori was made. The methods analysed are aimed at improving quality characteristics and obtaining new kinds of biomaterials to meet the needs of regenerative medicine and biomedicine. The diversity of biotechnological solutions that allow to gain a wide spectrum of biomaterials (incl. derivatives of cocoon shell such as fibroin, sericin and their composites; recombinant derivatives; antimicrobial peptides; modified transgenic silk fibres;transgenic fibres that contain growth factors and peptides; etc.) is a unique basis for the bioindustrial platform on the B. mori basis.

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The authors declare that there are no conflicts of interest present.