regmedjournalРегенерация органов и тканейРегенерация органов и тканей2949-5938Общество регенеративной медицины10.60043/2949-5938-2024-1-29-45regmedjournal-50Research ArticleОБЗОРЫ И КОММЕНТАРИИREVIEWS AND COMMENTSМетоды экстракции морского коллагена для решения задач регенеративной медициныMarine collagen extraction methods for solving regenerative medicine problemsКуликоваЮ. В.KulikovaYu. V.

Куликова Юлия Владимировна — старший научный сотрудник

236016, Калининград, улица Александра Невского, д. 14

Yuliya V. Kulikova — senior Researcher REC “Industrial Biotechnologies”

Alexander Nevsky Str., 14, 236041, Kaliningrad

СухихС. А.SukhikhS. A.

Сухих Станислав Алексеевич — заведующий лабораторией микробиологии и биотехнологий

236016, Калининград, улица Александра Невского, д. 14

Stanislav А. Sukhikh — Head of the Laboratory of Microbiology and Biotechnology

Alexander Nevsky Str., 14, 236041, Kaliningrad

stas-asp@mail.ruБабичО. О.BabichO. O.

Бабич Ольга Олеговна — директор

236016, Калининград, улица Александра Невского, д. 14

Olga О. Babich — director

Alexander Nevsky Str., 14, 236041, Kaliningrad

НОЦ «Промышленные биотехнологии», ФГБОУ ВО «Балтийский федеральный университет имени Иммануила Канта»РоссияREC “Industrial Biotechnologies”, Immanuel Kant Baltic Federal UniversityRussian Federation202412102024212945Copyright © Куликова Ю.В., Сухих С.А., Бабич О.О., 20242024Куликова Ю.В., Сухих С.А., Бабич О.О.Kulikova Y.V., Sukhikh S.A., Babich O.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.regmed-journal.ru/jour/article/view/50

Современная регенеративная медицина широко использует продукты и изделия на основе коллагена, наиболее популярным является коллаген животного происхождения. Использование такого коллагена сопряжено с  рядом трудностей, в  том числе с  возникновением активных иммунных реакций, а  также с  ограничениями религиозного и  культурного характера, не позволяющими использовать препараты, изготовленные из тканей животных. Удачной альтернативой коллагену из животных источников может служить морской коллаген, лишенный указанных недостатков. Сложившаяся геополитическая обстановка заставляет искать отечественные источники коллагена. В  статье представлен обзор методов экстракции коллагена из биомассы медуз. Рассмотрены перспективные виды медуз, пригодные для реализации указанных методов. Показано, что на территории РФ наиболее продуктивным и перспективным следует считать медуз семейства Rhizostomatidae отряда корнероты (Rhizostoma pulmo), обитающих в  Черном море. Медуза Aurelia aurita отряда дискомедуз (Semaeostomeae), несмотря на свою распространенность (обитает почти во всех морях России), имеет низкое содержание сухих веществ в биомассе и сложна в добыче из-за маленького веса особей. Из рассмотренных методов экстракции применительно к  биомассе медуз наиболее подходящей следует считать смешанную ферментативную и кислотную с использованием органических кислот экстракцию. Ферментативный метод с использованием пепсина применим к биомассе медуз Aurelia aurita, так как биомасса медуз полностью растворяется на первой стадии ферментативной экстракции.

Modern regenerative medicine widely uses collagen-based products and products, the most popular being collagen of animal origin. The use of such collagen is associated with a number of difficulties, incl. with the occurrence of active immune reactions, as well as with religious and cultural restrictions that do not allow the use of drugs made from animal tissue. Marine collagen, which does not have these disadvantages, can be a successful alternative to collagen from animal sources. The current geopolitical situation forces us to look for domestic sources of collagen. The article provides an overview of methods for extracting collagen from jellyfish biomass. Promising species of jellyfish suitable for implementing these methods are considered. It has been shown that on the territory of the Russian Federation, the most productive and promising jellyfish of the family Rhizostomatidae of the order of Rhizostoma pulmo, living in the Black Sea. The jellyfish Aurelia aurita of the order of disc jellyfish (Semaeostomeae), despite its prevalence (lives in almost all seas of Russia), has a low content of dry substances in its biomass and is difficult to catch due to the small weight of individuals. Of the extraction methods considered in relation to jellyfish biomass, mixed enzymatic and acidic extraction using organic acids should be considered the most suitable. The enzymatic method using pepsin is applicable to the biomass of Aurelia aurita jellyfish, because The jellyfish biomass is completely dissolved in the first stage of enzymatic extraction.

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The authors declare that there are no conflicts of interest present.