regmedjournalРегенерация органов и тканейРегенерация органов и тканей2949-5938Общество регенеративной медицины10.60043/2949-5938-2024-1-46-53regmedjournal-51Research ArticleОБРАЗОВАТЕЛЬНЫЙ ЛАНДШАФТ РЕГЕНЕРАТИВНОЙ МЕДИЦИНЫEDUCATIONAL LANDSCAPE OF REGENERATIVE MEDICINEЭпиморфная регенерация дистальной фаланги пальца у млекопитающихEpimorphic regeneration of mammalian digit tipАнтроповаЮ. Г.AntropovaJ. G.

Антропова Юлия Георгиевна — к.б.н., с.н.с. лаборатории генных и клеточных технологий кафедры биохимии и регенеративной биомедицины факультета фундаментальной медицины

Ломоносовский пр-т, 27 к 1, 119192, Москва

Julia G. Antropova — Ph.D. in Biology, senior research scientist, Laboratory of Gene and Cell Technologies, Biochemistry and Regenerative Medicine Chair, Faculty of Medicine

27-1, Lomonosovsky av., 119192, Moscow

ЕремичевР. Ю.EremichevR. Yu.

Еремичев Роман Юрьевич — к.м.н., м.н.с. лаборатории генно-клеточной терапии Института регенеративной медицины Медицинского научно-образовательного центра

Ломоносовский пр-т, 27 к 1, 119192, Москва

Roman Yu. Eremichev — M.D., Ph.D., junior research scientist, Laboratory of Gene and Cell Therapy, Center of Regenerative Medicine, Medical Scientific and Educational Institute

27-1, Lomonosovsky av., 119192, Moscow

МакаревичП. И.MakarevichP. I.

Макаревич Павел Игоревич — д.м.н., заведующий лабораторией генно-клеточной терапии Института регенеративной медицины Медицинского научно-образовательного центра

Ломоносовский пр-т, 27 к 1, 119192, Москва

Pavel I. Makarevich — M.D., D.Sc., Head of the Laboratory of Gene and Cell Therapy, Medical Scientific and Educational Institute

27-1, Lomonosovsky av., 119192, Moscow

КалининаН. И.KalininaN. I.

Калинина Наталья Игоревна — к.б.н., в.н.с. лаборатории генных и клеточных технологий кафедры биохимии и регенеративной биомедицины факультета фундаментальной медицины

Ломоносовский пр-т, 27 к 1, 119192, Москва

Natalia I. Kalinina — Ph.D. in Biology, leading research scientist, Laboratory of Gene and Cell Technologies, Biochemistry and Regenerative Medicine Chair, Faculty of Medicine

27-1, Lomonosovsky av., 119192, Moscow

n_i_kalinina@mail.ruМедицинский научно-образовательный институт ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияMedical Research and Educational Institute, Lomonosov Moscow State UniversityRussian Federation202412102024214653Copyright © Антропова Ю.Г., Еремичев Р.Ю., Макаревич П.И., Калинина Н.И., 20242024Антропова Ю.Г., Еремичев Р.Ю., Макаревич П.И., Калинина Н.И.Antropova J.G., Eremichev R.Y., Makarevich P.I., Kalinina N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.regmed-journal.ru/jour/article/view/51

В статье представлены материалы лекции о механизмах регенерации из учебного пособия «Лекции по регенеративной медицине». Рассмотрен пример эпиморфной регенерации у млекопитающих — клеточные механизмы восстановления тканей кончика пальца после ампутации. Эта модель является актуальным объектом исследований, поскольку позволяет изучать механизмы как формирования специализированной временной структуры бластемы, так и  последующего морфогенеза, который завершается полноценным восстановлением всех ампутированных тканей.

The article presents lecture materials on regeneration mechanisms from the textbook “Lectures on Regenerative Medicine”. An example of epimorphic regeneration in mammals is considered — the cellular mechanisms of tissue restoration of the fingertip after amputation. This model is a relevant object of research, since it allows us to study the mechanisms of both the formation of a specialized temporary structure of the blastema and subsequent morphogenesis, which ends with the full restoration of all amputated tissues.

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The authors declare that there are no conflicts of interest present.