regmedjournalРегенерация органов и тканейРегенерация органов и тканей2949-5938Общество регенеративной медицины10.60043/2949-5938-2024-2-11-32regmedjournal-68Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESМеханизмы участия микроРНК эндотелиальных клеток в регуляции ангиогенезаEndothelial cells microRNAs participation in the angiogenesis regulationКлимовичП. С.KlimovichP. S.

Климович Полина Сергеевна - к.б.н., старший научный сотрудник факультета фундаментальной медицины

119192, г. Москва, Ленинские горы, 1

121552 ул. Академика Чазова, 15а, Москва

Polina S. Klimovich - Cand. Sci. (Biology), Senior researcher of Faculty of Fundamental Medicine

Moscow, Leninskie Gory, 1, 119991

121552 St. Academician Chazova, 15А, Moscow

ДзреянВ. А.DzreyanV. A.

Дзреян Валентина Александровна - к.б.н., научный сотрудник факультета фундаментальной медицины

119192, г. Москва, Ленинские горы, 1

Valentina A. Dzreyan - Cand. Sci. (Biology), researcher of Faculty of Fundamental Medicine

Moscow, Leninskie Gory, 1, 119991

dzreyan2016@mail.ruСеминаЕ. В.SeminaE. V.

Семина Екатерина Владимировна - д.б.н., ведущий научный сотрудник факультета фундаментальной медицины

119192, г. Москва, Ленинские горы, 1

Ekaterina V. Semina - Dr. Sci. (Biology), Leading researcher of Faculty of Fundamental Medicine

Moscow, Leninskie Gory, 1, 119991

РубинаК. А.RubinaK. A.

Рубина Ксения Андреевна - д.б.н., заведующая лабораторией морфогенеза и репарации тканей факультета фундаментальной медицины

119192, г. Москва, Ленинские горы, 1

Kseniya A. Rubina - Dr. Sci. (Biology), Head of the laboratory of morphogenesis and tissue repair

Moscow, Leninskie Gory, 1, 119991

ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»; ФГБУ «Национальный медицинский исследовательский центр кардиологии имени академика Е.И. Чазова» Минздрава РоссииРоссияLomonosov Moscow State University; Chazov National Medical Research Centre of CardiologyRussian FederationФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияLomonosov Moscow State UniversityRussian Federation202422032025225981Copyright © Климович П.С., Дзреян В.А., Семина Е.В., Рубина К.А., 20252025Климович П.С., Дзреян В.А., Семина Е.В., Рубина К.А.Klimovich P.S., Dzreyan V.A., Semina E.V., Rubina K.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.regmed-journal.ru/jour/article/view/68

XX век ознаменовался пониманием того, что более 80% генов имеют дополнительную биологическую функцию в клетке, связанную с регуляцией экспрессии других генов. С таких генов могут экспрессироваться некодирующие регуляторные РНК различного типа, в том числе и микроРНК, способные изменять экспрессию белков в клетке. МикроРНК представляют собой одноцепочечные последовательности РНК длиной 20–25 нуклеотидов, которые регулируют экспрессию генов на посттранскрипционном уровне посредством деградации или репрессии трансляции целевой мРНК. В настоящем обзоре рассмотрены аспекты биогенеза микроРНК в клетках млекопитающих, а также их функции в эндотелиальных клетках и в регуляции ангиогенеза.

The 20th century marked the understanding that more than 80% of genes have an additional biological function in the cell associated with the regulation of the expression of other genes. Non-coding sequential-type RNA regulators, including microRNAs, capable of changing the expression of proteins in the cell, can be expressed with such genes. MicroRNAs are singlestranded RNA sequences 20–25 nucleotides in length that regulate gene expression at the posttranscriptional level through degradation or repression of mRNA translation. This review examines aspects of the biogenesis of microRNAs in mammalian cells, as well as their functions in endothelial cells and in the regulation of angiogenesis.

микроРНКнекодирующие РНКэндотелиальные клеткиангиогенезсосудыPlaur-miR1микроРНК сосудовmicroRNAnon-coding RNAendothelial cellsangiogenesisblood vesselsPlaurmiR1vascular microRNAРабота выполнена при финансовой поддержке Министерства здравоохранения РФ в рамках научного проекта ГЗ НИР № НИОКТР 124020200013-3 «Некодирующие РНК как перспективное направление в регуляции обновления и репарации сердечно-сосудистой системы».This work was supported by the Ministry of Health of the Russian Federation (state assignment SRW No. RTD 124020200013-3 “Non-coding RNAs as a promising tool for repair and regeneration of cardiovascular system”).ReferencesPelletier D, Rivera B, Fabian MR, Foulkes WD. miRNA biogenesis and inherited disorders: clinico-molecular insights. Trends Genet. 2023 May;39(5):401–414. DOI: 10.1016/j.tig.2023.01.009. Epub 2023 Feb 28. PMID: 36863945Pelletier D, Rivera B, Fabian MR, Foulkes WD. miRNA biogenesis and inherited disorders: clinico-molecular insights. Trends Genet. 2023 May;39(5):401–414. DOI: 10.1016/j.tig.2023.01.009. Epub 2023 Feb 28. PMID: 36863945Jafri I. MiRNA a New Insight in Metabolic and Human Diseases: A Review. Cell Mol Biol (Noisyle-grand). 2023 Aug 31;69(8):102–110. DOI: 10.14715/cmb/2023.69.8.16. PMID: 37715412Jafri I. MiRNA a New Insight in Metabolic and Human Diseases: A Review. Cell Mol Biol (Noisyle-grand). 2023 Aug 31;69(8):102–110. DOI: 10.14715/cmb/2023.69.8.16. PMID: 37715412Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004 Jan 23; 116(2):281–297. DOI: 10.1016/s0092-8674(04)00045-5. PMID: 14744438Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004 Jan 23; 116(2):281–297. DOI: 10.1016/s0092-8674(04)00045-5. PMID: 14744438Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24;403(6772):901–906. DOI: 10.1038/35002607. PMID: 10706289Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000 Feb 24;403(6772):901–906. DOI: 10.1038/35002607. PMID: 10706289Kozomara A, Birgaoanu M, Griffiths-Jones S. miRBase: from microRNA sequences to function. Nucleic Acids Res. 2019 Jan 8;47(D1):D155–D162. DOI: 10.1093/nar/gky1141. PMID: 30423142; PMCID: PMC6323917Kozomara A, Birgaoanu M, Griffiths-Jones S. miRBase: from microRNA sequences to function. Nucleic Acids Res. 2019 Jan 8;47(D1):D155–D162. DOI: 10.1093/nar/gky1141. PMID: 30423142; PMCID: PMC6323917Tastsoglou S, Alexiou A, Karagkouni D, Skoufos G, Zacharopoulou E, Hatzigeorgiou AG. DIANA-microT 2023: including predicted targets of virally encoded miRNAs. Nucleic Acids Res. 2023 Jul 5;51(W1):W148–W153. DOI: 10.1093/nar/gkad283. PMID: 37094027; PMCID: PMC10320106Tastsoglou S, Alexiou A, Karagkouni D, Skoufos G, Zacharopoulou E, Hatzigeorgiou AG. DIANA-microT 2023: including predicted targets of virally encoded miRNAs. Nucleic Acids Res. 2023 Jul 5;51(W1):W148–W153. DOI: 10.1093/nar/gkad283. PMID: 37094027; PMCID: PMC10320106Sen CK. MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine. Physiol Genomics. 2011 May 1;43(10):517–520. DOI: 10.1152/physiolgenomics.00037.2011. Epub 2011 Apr 5. PMID: 21467158; PMCID: PMC3110892Sen CK. MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine. Physiol Genomics. 2011 May 1;43(10):517–520. DOI: 10.1152/physiolgenomics.00037.2011. Epub 2011 Apr 5. PMID: 21467158; PMCID: PMC3110892Sun LL, Li WD, Lei FR, Li XQ. The regulatory role of microRNAs in angiogenesis-related diseases. J Cell Mol Med. 2018 Oct;22(10):4568–4587. DOI: 10.1111/jcmm.13700. Epub 2018 Jun 29. PMID: 29956461; PMCID: PMC6156236Sun LL, Li WD, Lei FR, Li XQ. The regulatory role of microRNAs in angiogenesis-related diseases. J Cell Mol Med. 2018 Oct;22(10):4568–4587. DOI: 10.1111/jcmm.13700. Epub 2018 Jun 29. PMID: 29956461; PMCID: PMC6156236Wang S, Olson EN. AngiomiRs--key regulators of angiogenesis. Curr Opin Genet Dev. 2009 Jun;19(3):205–211. DOI: 10.1016/j.gde.2009.04.002. Epub 2009 May 14. PMID: 19446450; PMCID: PMC2696563Wang S, Olson EN. AngiomiRs--key regulators of angiogenesis. Curr Opin Genet Dev. 2009 Jun;19(3):205–211. DOI: 10.1016/j.gde.2009.04.002. Epub 2009 May 14. PMID: 19446450; PMCID: PMC2696563Senger DR, Davis GE. Angiogenesis. Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a005090. DOI: 10.1101/cshperspect.a005090. PMID: 21807843; PMCID: PMC3140681Senger DR, Davis GE. Angiogenesis. Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a005090. DOI: 10.1101/cshperspect.a005090. PMID: 21807843; PMCID: PMC3140681Ghafouri-Fard S, Shoorei H, Mohaqiq M, Taheri M. Non-coding RNAs regulate angiogenic processes. Vascul Pharmacol. 2020 Oct-Nov;133-134:106778. DOI: 10.1016/j.vph.2020.106778. Epub 2020 Aug 9. PMID: 32784009Ghafouri-Fard S, Shoorei H, Mohaqiq M, Taheri M. Non-coding RNAs regulate angiogenic processes. Vascul Pharmacol. 2020 Oct-Nov;133-134:106778. DOI: 10.1016/j.vph.2020.106778. Epub 2020 Aug 9. PMID: 32784009Ahmed S, Kurusamy S, David ELS, Khan K, Kalyanakrishnan K, Ian-Gobo M, et al. Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by reducing pro-angiogenic but increasing anti-angiogenic gene expression. Sci Rep. 2022 Aug 30;12(1):14730. DOI: 10.1038/s41598-022-19172-x. PMID: 36042288; PMCID: PMC9427859Ahmed S, Kurusamy S, David ELS, Khan K, Kalyanakrishnan K, Ian-Gobo M, et al. Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by reducing pro-angiogenic but increasing anti-angiogenic gene expression. Sci Rep. 2022 Aug 30;12(1):14730. DOI: 10.1038/s41598-022-19172-x. PMID: 36042288; PMCID: PMC9427859Davis PJ, Leinung M., Mousa SA. Anti-Angiogenesis Strategies in Cancer Therapeutics. Academic Press (2017). 194 p, DOI https://doi.org/10.1016/C2014-0-02385-4Davis PJ, Leinung M., Mousa SA. Anti-Angiogenesis Strategies in Cancer Therapeutics. Academic Press (2017). 194 p, DOI https://doi.org/10.1016/C2014-0-02385-4Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, et al. Dicer is essential for mouse development. Nat Genet. 2003 Nov;35(3):215–217. DOI: 10.1038/ng1253. Epub 2003 Oct 5. Erratum in: Nat Genet. 2003 Nov;35(3):287. PMID: 14528307Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, et al. Dicer is essential for mouse development. Nat Genet. 2003 Nov;35(3):215–217. DOI: 10.1038/ng1253. Epub 2003 Oct 5. Erratum in: Nat Genet. 2003 Nov;35(3):287. PMID: 14528307Lam B, Nwadozi E, Haas TL, Birot O, Roudier E. High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism. Cells. 2021 Mar 27;10(4):742. DOI: 10.3390/cells10040742. PMID: 33801773; PMCID: PMC8065922Lam B, Nwadozi E, Haas TL, Birot O, Roudier E. High Glucose Treatment Limits Drosha Protein Expression and Alters AngiomiR Maturation in Microvascular Primary Endothelial Cells via an Mdm2-dependent Mechanism. Cells. 2021 Mar 27;10(4):742. DOI: 10.3390/cells10040742. PMID: 33801773; PMCID: PMC8065922Soufi-Zomorrod M, Hajifathali A, Kouhkan F, Mehdizadeh M, Rad SM, Soleimani M. MicroRNAs modulating angiogenesis: miR-129-1 and miR-133 act as angio-miR in HUVECs. Tumour Biol. 2016 Jul;37(7):9527–9534. DOI: 10.1007/s13277-016-4845-0. Epub 2016 Jan 20. PMID: 26790441Soufi-Zomorrod M, Hajifathali A, Kouhkan F, Mehdizadeh M, Rad SM, Soleimani M. MicroRNAs modulating angiogenesis: miR-129-1 and miR-133 act as angio-miR in HUVECs. Tumour Biol. 2016 Jul;37(7):9527–9534. DOI: 10.1007/s13277-016-4845-0. Epub 2016 Jan 20. PMID: 26790441Malan-Müller S, Hemmings SM, Seedat S. Big effects of small RNAs: a review of microRNAs in anxiety. Mol Neurobiol. 2013 Apr;47(2):726–739. DOI: 10.1007/s12035-012-8374-6. Epub 2012 Nov 13. PMID: 23150170; PMCID: PMC3589626Malan-Müller S, Hemmings SM, Seedat S. Big effects of small RNAs: a review of microRNAs in anxiety. Mol Neurobiol. 2013 Apr;47(2):726–739. DOI: 10.1007/s12035-012-8374-6. Epub 2012 Nov 13. PMID: 23150170; PMCID: PMC3589626Johnson KC, Johnson ST, Liu J, Chu Y, Arana C, Han Y, et al. Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs. RNA. 2023 Aug;29(8):1166–1184. DOI: 10.1261/rna.079647.123. Epub 2023 May 11. PMID: 37169394; PMCID: PMC10351893Johnson KC, Johnson ST, Liu J, Chu Y, Arana C, Han Y, et al. Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs. RNA. 2023 Aug;29(8):1166–1184. DOI: 10.1261/rna.079647.123. Epub 2023 May 11. PMID: 37169394; PMCID: PMC10351893Breving K, Esquela-Kerscher A. The complexities of microRNA regulation: mirandering around the rules. Int J Biochem Cell Biol. 2010 Aug;42(8):1316–1329. DOI: 10.1016/j.biocel.2009.09.016. Epub 2009 Sep 30. PMID: 19800023Breving K, Esquela-Kerscher A. The complexities of microRNA regulation: mirandering around the rules. Int J Biochem Cell Biol. 2010 Aug;42(8):1316–1329. DOI: 10.1016/j.biocel.2009.09.016. Epub 2009 Sep 30. PMID: 19800023Chan SP, Slack FJ. And now introducing mammalian mirtrons. Dev Cell. 2007 Nov;13(5):605–607. DOI: 10.1016/j.devcel.2007.10.010. PMID: 17981129Chan SP, Slack FJ. And now introducing mammalian mirtrons. Dev Cell. 2007 Nov;13(5):605–607. DOI: 10.1016/j.devcel.2007.10.010. PMID: 17981129Nakanishi K. Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins? Wiley Interdiscip Rev RNA. 2016 Sep;7(5):637–660. DOI: 10.1002/wrna.1356. Epub 2016 May 16. PMID: 27184117; PMCID: PMC5084781Nakanishi K. Anatomy of RISC: how do small RNAs and chaperones activate Argonaute proteins? Wiley Interdiscip Rev RNA. 2016 Sep;7(5):637–660. DOI: 10.1002/wrna.1356. Epub 2016 May 16. PMID: 27184117; PMCID: PMC5084781Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005 Dec;7(12):1261–1266. DOI: 10.1038/ncb1333. Epub 2005 Nov 13. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100. PMID: 16284623; PMCID: PMC1804202Liu J, Rivas FV, Wohlschlegel J, Yates JR 3rd, Parker R, Hannon GJ. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005 Dec;7(12):1261–1266. DOI: 10.1038/ncb1333. Epub 2005 Nov 13. Erratum in: Nat Cell Biol. 2006 Jan;8(1):100. PMID: 16284623; PMCID: PMC1804202Diao L, Marcais A, Norton S, Chen KC. MixMir: microRNA motif discovery from gene expression data using mixed linear models. Nucleic Acids Res. 2014;42(17):e135. DOI: 10.1093/nar/gku672. Epub 2014 Jul 31. PMID: 25081207; PMCID: PMC4176157Diao L, Marcais A, Norton S, Chen KC. MixMir: microRNA motif discovery from gene expression data using mixed linear models. Nucleic Acids Res. 2014;42(17):e135. DOI: 10.1093/nar/gku672. Epub 2014 Jul 31. PMID: 25081207; PMCID: PMC4176157Chawla G, Deosthale P, Childress S, Wu YC, Sokol NS. A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila. PLoS Genet. 2016 Aug 10;12(8): e1006247. DOI: 10.1371/journal.pgen.1006247. PMID: 27508495; PMCID: PMC4979967Chawla G, Deosthale P, Childress S, Wu YC, Sokol NS. A let-7-to-miR-125 MicroRNA Switch Regulates Neuronal Integrity and Lifespan in Drosophila. PLoS Genet. 2016 Aug 10;12(8): e1006247. DOI: 10.1371/journal.pgen.1006247. PMID: 27508495; PMCID: PMC4979967Sokol NS. Small temporal RNAs in animal development. Curr Opin Genet Dev. 2012 Aug; 22(4):368–373. DOI: 10.1016/j.gde.2012.04.001. Epub 2012 May 9. PMID: 22578317; PMCID: PMC3419770Sokol NS. Small temporal RNAs in animal development. Curr Opin Genet Dev. 2012 Aug; 22(4):368–373. DOI: 10.1016/j.gde.2012.04.001. Epub 2012 May 9. PMID: 22578317; PMCID: PMC3419770Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science. 2007 Dec 21;318(5858):1931–1934. DOI: 10.1126/science.1149460. Epub 2007 Nov 29. PMID: 18048652Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science. 2007 Dec 21;318(5858):1931–1934. DOI: 10.1126/science.1149460. Epub 2007 Nov 29. PMID: 18048652Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol. 2007 Mar;3(3):166–173. DOI: 10.1038/nchembio860. Epub 2007 Jan 28. PMID: 17259978Janowski BA, Younger ST, Hardy DB, Ram R, Huffman KE, Corey DR. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs. Nat Chem Biol. 2007 Mar;3(3):166–173. DOI: 10.1038/nchembio860. Epub 2007 Jan 28. PMID: 17259978Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, et al. Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA. 2006 Nov 14;103(46):17337–17342. DOI: 10.1073/pnas.0607015103. Epub 2006 Nov 3. PMID: 17085592; PMCID: PMC1859931Li LC, Okino ST, Zhao H, Pookot D, Place RF, Urakami S, et al. Small dsRNAs induce transcriptional activation in human cells. Proc Natl Acad Sci USA. 2006 Nov 14;103(46):17337–17342. DOI: 10.1073/pnas.0607015103. Epub 2006 Nov 3. PMID: 17085592; PMCID: PMC1859931Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS, Haussler D. Ultraconserved elements in the human genome. Science. 2004 May 28;304(5675):1321–1325. DOI: 10.1126/science.1098119. Epub 2004 May 6. PMID: 15131266Bejerano G, Pheasant M, Makunin I, Stephen S, Kent WJ, Mattick JS, Haussler D. Ultraconserved elements in the human genome. Science. 2004 May 28;304(5675):1321–1325. DOI: 10.1126/science.1098119. Epub 2004 May 6. PMID: 15131266Bozgeyik I. The dark matter of the human genome and its role in human cancers. Gene. 2022 Feb 15;811:146084. DOI: 10.1016/j.gene.2021.146084. Epub 2021 Nov 26. PMID: 34843880Bozgeyik I. The dark matter of the human genome and its role in human cancers. Gene. 2022 Feb 15;811:146084. DOI: 10.1016/j.gene.2021.146084. Epub 2021 Nov 26. PMID: 34843880Wang K, Zhang S, Weber J, Baxter D, Galas DJ. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. 2010 Nov;38(20):7248–7259. DOI: 10.1093/nar/gkq601. Epub 2010 Jul 7. PMID: 20615901; PMCID: PMC2978372Wang K, Zhang S, Weber J, Baxter D, Galas DJ. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. 2010 Nov;38(20):7248–7259. DOI: 10.1093/nar/gkq601. Epub 2010 Jul 7. PMID: 20615901; PMCID: PMC2978372Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011 Apr;13(4):423–433. DOI: 10.1038/ncb2210. Epub 2011 Mar 20. Erratum in: Nat Cell Biol. 2015 Jan;17(1):104. PMID: 21423178; PMCID: PMC3074610Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011 Apr;13(4):423–433. DOI: 10.1038/ncb2210. Epub 2011 Mar 20. Erratum in: Nat Cell Biol. 2015 Jan;17(1):104. PMID: 21423178; PMCID: PMC3074610Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007 Jun;9(6):654–659. DOI: 10.1038/ncb1596. Epub 2007 May 7. PMID: 17486113Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007 Jun;9(6):654–659. DOI: 10.1038/ncb1596. Epub 2007 May 7. PMID: 17486113Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 2012 Feb 12;14(3):249–256. DOI: 10.1038/ncb2441. PMID: 22327366Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 2012 Feb 12;14(3):249–256. DOI: 10.1038/ncb2441. PMID: 22327366Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009 Dec 8;2(100):ra81. DOI: 10.1126/scisignal.2000610. PMID: 19996457Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009 Dec 8;2(100):ra81. DOI: 10.1126/scisignal.2000610. PMID: 19996457Salido-Guadarrama I, Romero-Cordoba S, Peralta-Zaragoza O, Hidalgo-Miranda A, Rodríguez-Dorantes M. MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer. Onco Targets Ther. 2014 Jul 21;7:1327–1338. DOI: 10.2147/OTT.S61562. PMID: 25092989; PMCID: PMC4114916Salido-Guadarrama I, Romero-Cordoba S, Peralta-Zaragoza O, Hidalgo-Miranda A, Rodríguez-Dorantes M. MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer. Onco Targets Ther. 2014 Jul 21;7:1327–1338. DOI: 10.2147/OTT.S61562. PMID: 25092989; PMCID: PMC4114916Mayers JR, Audhya A. Vesicle formation within endosomes: An ESCRT marks the spot. Commun Integr Biol. 2012 Jan 1;5(1):50–56. DOI: 10.4161/cib.18208. PMID: 22482010; PMCID: PMC3291314Mayers JR, Audhya A. Vesicle formation within endosomes: An ESCRT marks the spot. Commun Integr Biol. 2012 Jan 1;5(1):50–56. DOI: 10.4161/cib.18208. PMID: 22482010; PMCID: PMC3291314Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008 Dec;10(12):1470–1476. DOI: 10.1038/ncb1800. Epub 2008 Nov 16. PMID: 19011622; PMCID: PMC3423894Skog J, Würdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008 Dec;10(12):1470–1476. DOI: 10.1038/ncb1800. Epub 2008 Nov 16. PMID: 19011622; PMCID: PMC3423894Shah MY, Calin GA. The mix of two worlds: non-coding RNAs and hormones. Nucleic Acid Ther. 2013 Feb;23(1):2–8. DOI: 10.1089/nat.2012.0375. Epub 2012 Oct 10. PMID: 23051203; PMCID: PMC3569955Shah MY, Calin GA. The mix of two worlds: non-coding RNAs and hormones. Nucleic Acid Ther. 2013 Feb;23(1):2–8. DOI: 10.1089/nat.2012.0375. Epub 2012 Oct 10. PMID: 23051203; PMCID: PMC3569955Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 2009 Nov;55(11):1944–1949. DOI: 10.1373/clinchem.2009.125310. Epub 2009 Aug 20. PMID: 19696117Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin Chem. 2009 Nov;55(11):1944–1949. DOI: 10.1373/clinchem.2009.125310. Epub 2009 Aug 20. PMID: 19696117Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA. 2011 Mar 22;108(12):5003–5008. DOI: 10.1073/pnas.1019055108. Epub 2011 Mar 7. PMID: 21383194; PMCID: PMC3064324Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA. 2011 Mar 22;108(12):5003–5008. DOI: 10.1073/pnas.1019055108. Epub 2011 Mar 7. PMID: 21383194; PMCID: PMC3064324Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330–9335. DOI: 10.1074/jbc.M413394200. Epub 2004 Dec 21. PMID: 15613470Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem. 2005 Mar 11;280(10):9330–9335. DOI: 10.1074/jbc.M413394200. Epub 2004 Dec 21. PMID: 15613470Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, et al. Dicerdependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14082–14087. DOI: 10.1073/pnas.0804597105. Epub 2008 Sep 8. PMID: 18779589; PMCID: PMC2544582Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, et al. Dicerdependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14082–14087. DOI: 10.1073/pnas.0804597105. Epub 2008 Sep 8. PMID: 18779589; PMCID: PMC2544582Rajewsky K, Gu H, Kühn R, Betz UA, Müller W, Roes J, Schwenk F. Conditional gene targeting. J Clin Invest. 1996 Aug 1;98(3):600–603. DOI: 10.1172/JCI118828. PMID: 8698848; PMCID: PMC507466Rajewsky K, Gu H, Kühn R, Betz UA, Müller W, Roes J, Schwenk F. Conditional gene targeting. J Clin Invest. 1996 Aug 1;98(3):600–603. DOI: 10.1172/JCI118828. PMID: 8698848; PMCID: PMC507466Cobb BS, Nesterova TB, Thompson E, Hertweck A, O’Connor E, Godwin J, et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 2;201(9):1367–1373. DOI: 10.1084/jem.20050572. PMID: 15867090; PMCID: PMC2213187Cobb BS, Nesterova TB, Thompson E, Hertweck A, O’Connor E, Godwin J, et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med. 2005 May 2;201(9):1367–1373. DOI: 10.1084/jem.20050572. PMID: 15867090; PMCID: PMC2213187Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001 Feb 15;230(2):230–242. DOI: 10.1006/dbio.2000.0106. PMID: 11161575Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, Yanagisawa M. Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol. 2001 Feb 15;230(2):230–242. DOI: 10.1006/dbio.2000.0106. PMID: 11161575Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn. 2006 Dec;235(12):3413–3422. DOI: 10.1002/dvdy.20982. PMID: 17072878Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn. 2006 Dec;235(12):3413–3422. DOI: 10.1002/dvdy.20982. PMID: 17072878Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of micro-RNAs. Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1050–H1059. DOI: 10.1152/ajpheart.00267.2012. Epub 2013 Feb 8. PMID: 23396454Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of micro-RNAs. Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1050–H1059. DOI: 10.1152/ajpheart.00267.2012. Epub 2013 Feb 8. PMID: 23396454Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res. 2007 Jul 6;101(1):59–68. DOI: 10.1161/CIRCRESAHA.107.153916. Epub 2007 May 31. PMID: 17540974Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res. 2007 Jul 6;101(1):59–68. DOI: 10.1161/CIRCRESAHA.107.153916. Epub 2007 May 31. PMID: 17540974Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, et al. MicroRNAs modulate the angiogenic properties of HUVECs. Blood. 2006 Nov 1;108(9):3068–3071. DOI: 10.1182/blood-2006-01-012369. Epub 2006 Jul 18. PMID: 16849646Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, et al. MicroRNAs modulate the angiogenic properties of HUVECs. Blood. 2006 Nov 1;108(9):3068–3071. DOI: 10.1182/blood-2006-01-012369. Epub 2006 Jul 18. PMID: 16849646Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, et al. VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 2016 Jan 8;118(1):38–47. DOI: 10.1161/CIRCRESAHA.115.307408. Epub 2015 Oct 15. PMID: 26472816; PMCID: PMC4703066Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, et al. VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 2016 Jan 8;118(1):38–47. DOI: 10.1161/CIRCRESAHA.115.307408. Epub 2015 Oct 15. PMID: 26472816; PMCID: PMC4703066Amini S, Abak A, Sakhinia E, Abhari A. MicroRNA-221 and MicroRNA-222 in Common Human Cancers: Expression, Function, and Triggering of Tumor Progression as a Key Modulator. Lab Med. 2019 Oct 10;50(4):333–347. DOI: 10.1093/labmed/lmz002. PMID: 31049571Amini S, Abak A, Sakhinia E, Abhari A. MicroRNA-221 and MicroRNA-222 in Common Human Cancers: Expression, Function, and Triggering of Tumor Progression as a Key Modulator. Lab Med. 2019 Oct 10;50(4):333–347. DOI: 10.1093/labmed/lmz002. PMID: 31049571Chistiakov DA, Orekhov AN, Bobryshev YV. The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease. J Mol Cell Cardiol. 2016 Aug;97:47–55. DOI: 10.1016/j.yjmcc.2016.05.007. Epub 2016 May 12. PMID: 27180261Chistiakov DA, Orekhov AN, Bobryshev YV. The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease. J Mol Cell Cardiol. 2016 Aug;97:47–55. DOI: 10.1016/j.yjmcc.2016.05.007. Epub 2016 May 12. PMID: 27180261Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, et al. The endothelial-specific micro-RNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261–271. DOI: 10.1016/j.devcel.2008.07.002. PMID: 18694565; PMCID: PMC2685763Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, et al. The endothelial-specific micro-RNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261–271. DOI: 10.1016/j.devcel.2008.07.002. PMID: 18694565; PMCID: PMC2685763Campagnolo L, Leahy A, Chitnis S, Koschnick S, Fitch MJ, Fallon JT, et al. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol. 2005 Jul;167(1):275–284. DOI: 10.1016/S0002-9440(10)62972-0. PMID: 15972971; PMCID: PMC1451775Campagnolo L, Leahy A, Chitnis S, Koschnick S, Fitch MJ, Fallon JT, et al. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am J Pathol. 2005 Jul;167(1):275–284. DOI: 10.1016/S0002-9440(10)62972-0. PMID: 15972971; PMCID: PMC1451775Soncin F, Mattot V, Lionneton F, Spruyt N, Lepretre F, Begue A, Stehelin D. VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J. 2003 Nov 3;22(21):5700–5711. DOI: 10.1093/emboj/cdg549. PMID: 14592969; PMCID: PMC275406Soncin F, Mattot V, Lionneton F, Spruyt N, Lepretre F, Begue A, Stehelin D. VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J. 2003 Nov 3;22(21):5700–5711. DOI: 10.1093/emboj/cdg549. PMID: 14592969; PMCID: PMC275406Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008 Dec;135(24):3989–3993. DOI: 10.1242/dev.029736. Epub 2008 Nov 5. PMID: 18987025Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008 Dec;135(24):3989–3993. DOI: 10.1242/dev.029736. Epub 2008 Nov 5. PMID: 18987025Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug;15(2):272–284. DOI: 10.1016/j.devcel.2008.07.008. PMID: 18694566; PMCID: PMC2604134Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug;15(2):272–284. DOI: 10.1016/j.devcel.2008.07.008. PMID: 18694566; PMCID: PMC2604134Lu W, Du X, Zou S, Fang Q, Wu M, Li H, Shi B. IFN-γ enhances the therapeutic efficacy of MSCsderived exosome via miR-126-3p in diabetic wound healing by targeting SPRED1. J Diabetes. 2024 Jan;16(1):e13465. DOI: 10.1111/1753-0407.13465. Epub 2023 Aug 30. PMID: 37646268; PMCID: PMC10809290Lu W, Du X, Zou S, Fang Q, Wu M, Li H, Shi B. IFN-γ enhances the therapeutic efficacy of MSCsderived exosome via miR-126-3p in diabetic wound healing by targeting SPRED1. J Diabetes. 2024 Jan;16(1):e13465. DOI: 10.1111/1753-0407.13465. Epub 2023 Aug 30. PMID: 37646268; PMCID: PMC10809290Zhang J, Zhang Z, Zhang DY, Zhu J, Zhang T, Wang C. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS One. 2013 Dec 13;8(12):e83294. DOI: 10.1371/journal.pone.0083294. PMID: 24349482; PMCID: PMC3862723Zhang J, Zhang Z, Zhang DY, Zhu J, Zhang T, Wang C. microRNA 126 inhibits the transition of endothelial progenitor cells to mesenchymal cells via the PIK3R2-PI3K/Akt signalling pathway. PLoS One. 2013 Dec 13;8(12):e83294. DOI: 10.1371/journal.pone.0083294. PMID: 24349482; PMCID: PMC3862723Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010 Apr 22; 464(7292):1196–1200. DOI: 10.1038/nature08889. Epub 2010 Apr 4. Erratum in: Nature. 2010 Sep 16;467(7313):356. PMID: 20364122; PMCID: PMC2914488Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010 Apr 22; 464(7292):1196–1200. DOI: 10.1038/nature08889. Epub 2010 Apr 4. Erratum in: Nature. 2010 Sep 16;467(7313):356. PMID: 20364122; PMCID: PMC2914488Kumar S, Kim CW, Simmons RD, Jo H. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2206–2216. DOI: 10.1161/ATVBAHA.114.303425. Epub 2014 Jul 10. PMID: 25012134; PMCID: PMC4169332Kumar S, Kim CW, Simmons RD, Jo H. Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2206–2216. DOI: 10.1161/ATVBAHA.114.303425. Epub 2014 Jul 10. PMID: 25012134; PMCID: PMC4169332Kobus K, Kopycinska J, Kozlowska-Wiechowska A, Urasinska E, Kempinska-Podhorodecka A, Haas TL, et al. Angiogenesis within the duodenum of patients with cirrhosis is modulated by mechanosensitive Kruppel-like factor 2 and microRNA-126. Liver Int. 2012 Sep;32(8):1222–1232. DOI: 10.1111/j.1478-3231.2012.02791.x. Epub 2012 May 10. PMID: 22574900Kobus K, Kopycinska J, Kozlowska-Wiechowska A, Urasinska E, Kempinska-Podhorodecka A, Haas TL, et al. Angiogenesis within the duodenum of patients with cirrhosis is modulated by mechanosensitive Kruppel-like factor 2 and microRNA-126. Liver Int. 2012 Sep;32(8):1222–1232. DOI: 10.1111/j.1478-3231.2012.02791.x. Epub 2012 May 10. PMID: 22574900Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA. 2008 Feb 5;105(5):1516–1521. DOI: 10.1073/pnas.0707493105. Epub 2008 Jan 28. PMID: 18227515; PMCID: PMC2234176Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci USA. 2008 Feb 5;105(5):1516–1521. DOI: 10.1073/pnas.0707493105. Epub 2008 Jan 28. PMID: 18227515; PMCID: PMC2234176Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, et al. MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1630–1639. DOI: 10.1152/ajprenal.00400.2011. Epub 2012 Mar 14. PMID: 22419694Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, et al. MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1630–1639. DOI: 10.1152/ajprenal.00400.2011. Epub 2012 Mar 14. PMID: 22419694Yue S, Shi H, Han J, Zhang T, Zhu W, Zhang D. Prognostic value of microRNA-126 and CRK expression in gastric cancer. Onco Targets Ther. 2016 Oct 11;9:6127–6135. DOI: 10.2147/OTT.S87778. PMID: 27785060; PMCID: PMC5066993Yue S, Shi H, Han J, Zhang T, Zhu W, Zhang D. Prognostic value of microRNA-126 and CRK expression in gastric cancer. Onco Targets Ther. 2016 Oct 11;9:6127–6135. DOI: 10.2147/OTT.S87778. PMID: 27785060; PMCID: PMC5066993Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, et al. miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway. Animals (Basel). 2021 Jul 30;11(8):2260. DOI: 10.3390/ani11082260. PMID: 34438716; PMCID: PMC8388524Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, et al. miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway. Animals (Basel). 2021 Jul 30;11(8):2260. DOI: 10.3390/ani11082260. PMID: 34438716; PMCID: PMC8388524Miko E, Margitai Z, Czimmerer Z, Várkonyi I, Dezso B, Lányi A, et al. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett. 2011 Apr 20; 585(8):1191–1196. DOI: 10.1016/j.febslet.2011.03.039. Epub 2011 Mar 23. PMID: 21439283Miko E, Margitai Z, Czimmerer Z, Várkonyi I, Dezso B, Lányi A, et al. miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5. FEBS Lett. 2011 Apr 20; 585(8):1191–1196. DOI: 10.1016/j.febslet.2011.03.039. Epub 2011 Mar 23. PMID: 21439283Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, et al. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21;113(1):40–51. DOI: 10.1161/CIRCRESAHA.113.280883. Epub 2013 Apr 19. PMID: 23603512; PMCID: PMC3772783Zhou J, Li YS, Nguyen P, Wang KC, Weiss A, Kuo YC, et al. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013 Jun 21;113(1):40–51. DOI: 10.1161/CIRCRESAHA.113.280883. Epub 2013 Apr 19. PMID: 23603512; PMCID: PMC3772783Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, et al. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014 Apr;20(4):368–376. DOI: 10.1038/nm.3487. Epub 2014 Mar 2. PMID: 24584117; PMCID: PMC4398028Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, et al. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014 Apr;20(4):368–376. DOI: 10.1038/nm.3487. Epub 2014 Mar 2. PMID: 24584117; PMCID: PMC4398028Li P, Yin YL, Guo T, Sun XY, Ma H, Zhu ML, et al. Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo. Circulation. 2016 Nov 29;134(22):1752–1765. DOI: 10.1161/CIRCULATIONAHA.116.017949. Epub 2016 Oct 20. PMID: 27765794; PMCID: PMC5120771Li P, Yin YL, Guo T, Sun XY, Ma H, Zhu ML, et al. Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo. Circulation. 2016 Nov 29;134(22):1752–1765. DOI: 10.1161/CIRCULATIONAHA.116.017949. Epub 2016 Oct 20. PMID: 27765794; PMCID: PMC5120771Chen L, Liu C, Sun D, Wang T, Zhao L, Chen W, et al. MicroRNA-133a impairs perfusion recovery after hindlimb ischemia in diabetic mice. Biosci Rep. 2018 Jul 2;38(4):BSR20180346. DOI: 10.1042/BSR20180346. PMID: 29789398; PMCID: PMC6028757Chen L, Liu C, Sun D, Wang T, Zhao L, Chen W, et al. MicroRNA-133a impairs perfusion recovery after hindlimb ischemia in diabetic mice. Biosci Rep. 2018 Jul 2;38(4):BSR20180346. DOI: 10.1042/BSR20180346. PMID: 29789398; PMCID: PMC6028757Zhu W, Sun L, Zhao P, Liu Y, Zhang J, Zhang Y, et al. Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p. J Nanobiotechnology. 2021 Feb 27; 19(1):61. DOI: 10.1186/s12951-021-00808-5. PMID: 33639970; PMCID: PMC7916292Zhu W, Sun L, Zhao P, Liu Y, Zhang J, Zhang Y, et al. Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p. J Nanobiotechnology. 2021 Feb 27; 19(1):61. DOI: 10.1186/s12951-021-00808-5. PMID: 33639970; PMCID: PMC7916292Nikolajevic J, Ariaee N, Liew A, Abbasnia S, Fazeli B, Sabovic M. The Role of MicroRNAs in Endothelial Cell Senescence. Cells. 2022 Mar 31;11(7):1185. DOI: 10.3390/cells11071185. PMID: 35406749; PMCID: PMC8997793Nikolajevic J, Ariaee N, Liew A, Abbasnia S, Fazeli B, Sabovic M. The Role of MicroRNAs in Endothelial Cell Senescence. Cells. 2022 Mar 31;11(7):1185. DOI: 10.3390/cells11071185. PMID: 35406749; PMCID: PMC8997793Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, Amati F, et al. Micro-RNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation. 2009 Oct 13;120(15):1524–1532. DOI: 10.1161/CIRCULATIONAHA.109.864629. Epub 2009 Sep 28. PMID: 19786632Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, Amati F, et al. Micro-RNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation. 2009 Oct 13;120(15):1524–1532. DOI: 10.1161/CIRCULATIONAHA.109.864629. Epub 2009 Sep 28. PMID: 19786632Rysenkova KD, Troyanovskiy KE, Klimovich PS, Bulyakova TR, Shelomentseva EM, Shmakova AA, et al. Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Plaur) and Its Molecular Target Mef2d. Front Mol Neurosci. 2022 Jul 6;15:865858. DOI: 10.3389/fnmol.2022.865858. PMID: 35875662; PMCID: PMC9298986Rysenkova KD, Troyanovskiy KE, Klimovich PS, Bulyakova TR, Shelomentseva EM, Shmakova AA, et al. Identification of a Novel Small RNA Encoded in the Mouse Urokinase Receptor uPAR Gene (Plaur) and Its Molecular Target Mef2d. Front Mol Neurosci. 2022 Jul 6;15:865858. DOI: 10.3389/fnmol.2022.865858. PMID: 35875662; PMCID: PMC9298986Larusch GA, Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin RG, Cines DB, Schmaier AH. Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H305–H320. DOI: 10.1152/ajpheart.00110.2013. Epub 2013 May 24. PMID: 23709605; PMCID: PMC3742872Larusch GA, Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin RG, Cines DB, Schmaier AH. Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H305–H320. DOI: 10.1152/ajpheart.00110.2013. Epub 2013 May 24. PMID: 23709605; PMCID: PMC3742872Semina E, Rubina K, Sysoeva V, Rysenkova K, Klimovich P, Plekhanova O, Tkachuk V. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295–310. DOI: 10.1016/j.ejcb.2016.05.003. Epub 2016 Jun 3. PMID: 27324124Semina E, Rubina K, Sysoeva V, Rysenkova K, Klimovich P, Plekhanova O, Tkachuk V. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295–310. DOI: 10.1016/j.ejcb.2016.05.003. Epub 2016 Jun 3. PMID: 27324124Klimovich PS, Semina EV, Karagyaur MN, Rysenkova KD, Sysoeva VY, Mironov NA, et al. Urokinase receptor regulates nerve regeneration through its interaction with α5β1-integrin. Biomed Pharmacother. 2020 May;125:110008. DOI: 10.1016/j.biopha.2020.110008. Epub 2020 Feb 28. PMID: 32187956Klimovich PS, Semina EV, Karagyaur MN, Rysenkova KD, Sysoeva VY, Mironov NA, et al. Urokinase receptor regulates nerve regeneration through its interaction with α5β1-integrin. Biomed Pharmacother. 2020 May;125:110008. DOI: 10.1016/j.biopha.2020.110008. Epub 2020 Feb 28. PMID: 32187956Rysenkova KD, Klimovich PS, Shmakova AA, Karagyaur MN, Ivanova KA, Aleksandrushkina NA, et al. Urokinase receptor deficiency results in EGFR-mediated failure to transmit signals for cell survival and neurite formation in mouse neuroblastoma cells. Cell Signal. 2020 Nov;75:109741. DOI: 10.1016/j.cellsig.2020.109741. Epub 2020 Aug 18. PMID: 32822758Rysenkova KD, Klimovich PS, Shmakova AA, Karagyaur MN, Ivanova KA, Aleksandrushkina NA, et al. Urokinase receptor deficiency results in EGFR-mediated failure to transmit signals for cell survival and neurite formation in mouse neuroblastoma cells. Cell Signal. 2020 Nov;75:109741. DOI: 10.1016/j.cellsig.2020.109741. Epub 2020 Aug 18. PMID: 32822758Dzhauari S, Litvinova S, Efimenko A, Aleksandrushkina N, Basalova N, Abakumov M, et al. Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage. Biomedicines. 2022 Jun 8;10(6):1346. DOI: 10.3390/biomedicines10061346. PMID: 35740368; PMCID: PMC9220139Dzhauari S, Litvinova S, Efimenko A, Aleksandrushkina N, Basalova N, Abakumov M, et al. Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage. Biomedicines. 2022 Jun 8;10(6):1346. DOI: 10.3390/biomedicines10061346. PMID: 35740368; PMCID: PMC9220139Shmakova A, Balatskiy A, Kulebyakina M., et al. Urokinase Receptor uPAR Overexpression in Mouse Brain Stimulates the Migration of Neurons into the Cortex during Embryogenesis. Russ J Dev Biol 2021;52:53–63. DOI: 10.1134/S1062360421010069Shmakova A, Balatskiy A, Kulebyakina M., et al. Urokinase Receptor uPAR Overexpression in Mouse Brain Stimulates the Migration of Neurons into the Cortex during Embryogenesis. Russ J Dev Biol 2021;52:53–63. DOI: 10.1134/S1062360421010069Karagyaur M, Dyikanov D, Makarevich P, Semina E, Stambolsky D, Plekhanova O, et al. Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration. Biomed Pharmacother. 2015 Aug;74:63–70. DOI: 10.1016/j.biopha.2015.07.002. Epub 2015 Jul 28. PMID: 26349964Karagyaur M, Dyikanov D, Makarevich P, Semina E, Stambolsky D, Plekhanova O, et al. Non-viral transfer of BDNF and uPA stimulates peripheral nerve regeneration. Biomed Pharmacother. 2015 Aug;74:63–70. DOI: 10.1016/j.biopha.2015.07.002. Epub 2015 Jul 28. PMID: 26349964Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood. 2004 Feb 1;103(3):955–962. DOI: 10.1182/blood-2003-07-2214. Epub 2003 Oct 2. PMID: 14525763Prager GW, Breuss JM, Steurer S, Mihaly J, Binder BR. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood. 2004 Feb 1;103(3):955–962. DOI: 10.1182/blood-2003-07-2214. Epub 2003 Oct 2. PMID: 14525763Dergilev KV, Beloglazova IB, Tsokolaeva ZI, Vasilets YD, Parfenova EV. Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart. Bull Exp Biol Med. 2022 May;173(1):5–9. DOI: 10.1007/s10517-022-05480-9. Epub 2022 May 27. PMID: 35622258Dergilev KV, Beloglazova IB, Tsokolaeva ZI, Vasilets YD, Parfenova EV. Deficiency of Urokinase-Type Plasminogen Activator Receptor Is Associated with the Development of Perivascular Fibrosis in Mouse Heart. Bull Exp Biol Med. 2022 May;173(1):5–9. DOI: 10.1007/s10517-022-05480-9. Epub 2022 May 27. PMID: 35622258Kjaergaard M, Hansen LV, Jacobsen B, Gardsvoll H, Ploug M. Structure and ligand interactions of the urokinase receptor (uPAR). Front Biosci. 2008 May 1;13:5441–5461. DOI: 10.2741/3092. PMID: 18508598Kjaergaard M, Hansen LV, Jacobsen B, Gardsvoll H, Ploug M. Structure and ligand interactions of the urokinase receptor (uPAR). Front Biosci. 2008 May 1;13:5441–5461. DOI: 10.2741/3092. PMID: 18508598Chu Y, Kilikevicius A, Liu J, Johnson KC, Yokota S, Corey DR. Argonaute binding within 3’-untranslated regions poorly predicts gene repression. Nucleic Acids Res. 2020 Jul 27; 48(13):7439–7453. DOI: 10.1093/nar/gkaa478. PMID: 32501500; PMCID: PMC7367155Chu Y, Kilikevicius A, Liu J, Johnson KC, Yokota S, Corey DR. Argonaute binding within 3’-untranslated regions poorly predicts gene repression. Nucleic Acids Res. 2020 Jul 27; 48(13):7439–7453. DOI: 10.1093/nar/gkaa478. PMID: 32501500; PMCID: PMC7367155Faezeh Jame-Chenarboo, Hoi Hei Ng, Dawn Macdonald, Lara K. Mahal. miRNA upregulate protein and glycan expression via direct activation in proliferating cells. bioRxiv. 2022.04.01.486772; doi: https://doi.org/10.1101/2022.04.01.486772Faezeh Jame-Chenarboo, Hoi Hei Ng, Dawn Macdonald, Lara K. Mahal. miRNA upregulate protein and glycan expression via direct activation in proliferating cells. bioRxiv. 2022.04.01.486772; doi: https://doi.org/10.1101/2022.04.01.486772Basalova N. et al. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer. Exp Mol Med. 2023 Jul;55(7):1399–1412. DOI: 10.1038/s12276-023-01017-w. Epub 2023 Jul 3. PMID: 37394579; PMCID: PMC10393964Basalova N. et al. Mesenchymal stromal cells facilitate resolution of pulmonary fibrosis by miR-29c and miR-129 intercellular transfer. Exp Mol Med. 2023 Jul;55(7):1399–1412. DOI: 10.1038/s12276-023-01017-w. Epub 2023 Jul 3. PMID: 37394579; PMCID: PMC10393964Kanugula AK, Adapala RK, Guarino BD, Bhavnani N, Dudipala H, Paruchuri S, Thodeti CK. Studying Angiogenesis Using Matrigel In Vitro and In Vivo. Methods Mol Biol. 2024;2711:105–116. DOI: 10.1007/978-1-0716-3429-5_9. PMID: 37776452Kanugula AK, Adapala RK, Guarino BD, Bhavnani N, Dudipala H, Paruchuri S, Thodeti CK. Studying Angiogenesis Using Matrigel In Vitro and In Vivo. Methods Mol Biol. 2024;2711:105–116. DOI: 10.1007/978-1-0716-3429-5_9. PMID: 37776452Mehta V, Mahmoud M. Ex Vivo Mouse Aortic Ring Angiogenesis Assay. Methods Mol Biol. 2022;2475:229–238. DOI: 10.1007/978-1-0716-2217-9_17. PMID: 35451762Mehta V, Mahmoud M. Ex Vivo Mouse Aortic Ring Angiogenesis Assay. Methods Mol Biol. 2022;2475:229–238. DOI: 10.1007/978-1-0716-2217-9_17. PMID: 35451762Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):223–232. DOI: 10.1161/ATVBAHA.107.158014. Epub 2007 Dec 27. PMID: 18162609Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):223–232. DOI: 10.1161/ATVBAHA.107.158014. Epub 2007 Dec 27. PMID: 18162609Nicosia RF. The aortic ring model of angiogenesis: a quarter century of search and discovery. J Cell Mol Med. 2009 Oct;13(10):4113–4136. DOI: 10.1111/j.1582-4934.2009.00891.x. Epub 2009 Sep 1. PMID: 19725916; PMCID: PMC4496118Nicosia RF. The aortic ring model of angiogenesis: a quarter century of search and discovery. J Cell Mol Med. 2009 Oct;13(10):4113–4136. DOI: 10.1111/j.1582-4934.2009.00891.x. Epub 2009 Sep 1. PMID: 19725916; PMCID: PMC4496118Celluzzi A, Paolini A, D’Oria V, Risoluti R, Materazzi S, Pezzullo M, et al. Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells. Int J Nanomedicine. 2017 Dec 18;13:1–18. DOI: 10.2147/IJN.S144155. Erratum in: Int J Nanomedicine. 2018 Jun 27;13:3729. DOI: 10.2147/IJN.S172673. PMID: 29296082; PMCID: PMC5739113Celluzzi A, Paolini A, D’Oria V, Risoluti R, Materazzi S, Pezzullo M, et al. Biophysical and biological contributions of polyamine-coated carbon nanotubes and bidimensional buckypapers in the delivery of miRNAs to human cells. Int J Nanomedicine. 2017 Dec 18;13:1–18. DOI: 10.2147/IJN.S144155. Erratum in: Int J Nanomedicine. 2018 Jun 27;13:3729. DOI: 10.2147/IJN.S172673. PMID: 29296082; PMCID: PMC5739113Masotti A, Miller MR, Celluzzi A, Rose L, Micciulla F, Hadoke PW, et al. Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes. Nanomedicine. 2016 Aug;12(6):1511–1522. DOI: 10.1016/j.nano.2016.02.017. Epub 2016 Mar 22. PMID: 27013131; PMCID: PMC4949379Masotti A, Miller MR, Celluzzi A, Rose L, Micciulla F, Hadoke PW, et al. Regulation of angiogenesis through the efficient delivery of microRNAs into endothelial cells using polyamine-coated carbon nanotubes. Nanomedicine. 2016 Aug;12(6):1511–1522. DOI: 10.1016/j.nano.2016.02.017. Epub 2016 Mar 22. PMID: 27013131; PMCID: PMC4949379Aday S, Hazan-Halevy I, Chamorro-Jorganes A, Anwar M, Goldsmith M, Beazley-Long N, et al. Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo. Mol Ther. 2021 Jul 7;29(7):2239–2252. DOI: 10.1016/ j.ymthe.2021.03.015. Epub 2021 Mar 18. PMID: 33744469; PMCID: PMC8261169Aday S, Hazan-Halevy I, Chamorro-Jorganes A, Anwar M, Goldsmith M, Beazley-Long N, et al. Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivo. Mol Ther. 2021 Jul 7;29(7):2239–2252. DOI: 10.1016/ j.ymthe.2021.03.015. Epub 2021 Mar 18. PMID: 33744469; PMCID: PMC8261169Sadowska JM, Ziminska M, Ferreira C, Matheson A, Balouch A, Bogle J, et al. Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms. Biomaterials. 2023 Dec;303:122398. DOI: 10.1016/j.biomaterials.2023.122398. Epub 2023 Nov 13. PMID: 37979514Sadowska JM, Ziminska M, Ferreira C, Matheson A, Balouch A, Bogle J, et al. Development of miR-26a-activated scaffold to promote healing of critical-sized bone defects through angiogenic and osteogenic mechanisms. Biomaterials. 2023 Dec;303:122398. DOI: 10.1016/j.biomaterials.2023.122398. Epub 2023 Nov 13. PMID: 37979514Xiong QH, Zhao L, Wan GQ, Hu YG, Li XL. Engineered BMSCs-Derived Exosomal miR-542-3p Promotes Cutaneous Wound Healing. Endocr Metab Immune Disord Drug Targets. 2023;23(3):336–346. DOI: 10.2174/1871530322666220523151713. PMID: 35616673Xiong QH, Zhao L, Wan GQ, Hu YG, Li XL. Engineered BMSCs-Derived Exosomal miR-542-3p Promotes Cutaneous Wound Healing. Endocr Metab Immune Disord Drug Targets. 2023;23(3):336–346. DOI: 10.2174/1871530322666220523151713. PMID: 35616673Murata K, Ito H, Yoshitomi H, Yamamoto K, Fukuda A, Yoshikawa J, et al. Inhibition of miR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice. J Bone Miner Res. 2014 Feb;29(2):316–326. DOI: 10.1002/jbmr.2040. PMID: 23857760Murata K, Ito H, Yoshitomi H, Yamamoto K, Fukuda A, Yoshikawa J, et al. Inhibition of miR-92a enhances fracture healing via promoting angiogenesis in a model of stabilized fracture in young mice. J Bone Miner Res. 2014 Feb;29(2):316–326. DOI: 10.1002/jbmr.2040. PMID: 23857760Ding MH, Lozoya EG, Rico RN, Chew SA. The Role of Angiogenesis-Inducing microRNAs in Vascular Tissue Engineering. Tissue Eng Part A. 2020 Dec;26(23–24):1283–1302. DOI: 10.1089/ten.TEA.2020.0170. Epub 2020 Oct 1. PMID: 32762306Ding MH, Lozoya EG, Rico RN, Chew SA. The Role of Angiogenesis-Inducing microRNAs in Vascular Tissue Engineering. Tissue Eng Part A. 2020 Dec;26(23–24):1283–1302. DOI: 10.1089/ten.TEA.2020.0170. Epub 2020 Oct 1. PMID: 32762306Bonauer A, Boon RA, Dimmeler S. Vascular microRNAs. Curr Drug Targets. 2010 Aug; 11(8):943–49. DOI: 10.2174/138945010791591313. PMID: 20415654Bonauer A, Boon RA, Dimmeler S. Vascular microRNAs. Curr Drug Targets. 2010 Aug; 11(8):943–49. DOI: 10.2174/138945010791591313. PMID: 20415654Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res. 2007 Apr 27;100(8):1164–1173. DOI: 10.1161/01.RES.0000265065.26744.17. Epub 2007 Mar 22. PMID: 17379831Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res. 2007 Apr 27;100(8):1164–1173. DOI: 10.1161/01.RES.0000265065.26744.17. Epub 2007 Mar 22. PMID: 17379831Weber M, Baker MB, Moore JP, Searles CD. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun. 2010 Mar 19; 393(4):643–648. DOI: 10.1016/j.bbrc.2010.02.045. Epub 2010 Feb 12. PMID: 20153722; PMCID: PMC3717387Weber M, Baker MB, Moore JP, Searles CD. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem Biophys Res Commun. 2010 Mar 19; 393(4):643–648. DOI: 10.1016/j.bbrc.2010.02.045. Epub 2010 Feb 12. PMID: 20153722; PMCID: PMC3717387Yang P, Cai L, Zhang G, Bian Z, Han G. The role of the miR-17-92 cluster in neurogenesis and angiogenesis in the central nervous system of adults. J Neurosci Res. 2017 Aug;95(8):1574–1581. DOI: 10.1002/jnr.23991. Epub 2016 Nov 21. PMID: 27869313Yang P, Cai L, Zhang G, Bian Z, Han G. The role of the miR-17-92 cluster in neurogenesis and angiogenesis in the central nervous system of adults. J Neurosci Res. 2017 Aug;95(8):1574–1581. DOI: 10.1002/jnr.23991. Epub 2016 Nov 21. PMID: 27869313Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, et al. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci USA. 2010 Feb 16;107(7):3240–3244. DOI: 10.1073/pnas.0914882107. Epub 2010 Jan 27. PMID: 20133739; PMCID: PMC2840357Qin X, Wang X, Wang Y, Tang Z, Cui Q, Xi J, et al. MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin D1 expression in human umbilical vein endothelial cells. Proc Natl Acad Sci USA. 2010 Feb 16;107(7):3240–3244. DOI: 10.1073/pnas.0914882107. Epub 2010 Jan 27. PMID: 20133739; PMCID: PMC2840357Olivieri F, Lazzarini R, Recchioni R, Marcheselli F, Rippo MR, Di Nuzzo S, et al. Procopio AD. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr). 2013 Aug;35(4):1157–1172. DOI: 10.1007/s11357-012-9440-8. Epub 2012 Jun 13. PMID: 22692818; PMCID: PMC3705128Olivieri F, Lazzarini R, Recchioni R, Marcheselli F, Rippo MR, Di Nuzzo S, et al. Procopio AD. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr). 2013 Aug;35(4):1157–1172. DOI: 10.1007/s11357-012-9440-8. Epub 2012 Jun 13. PMID: 22692818; PMCID: PMC3705128Li J, Zhang Y, Zhao Q, Wang J, He X. MicroRNA-10a Influences Osteoblast Differentiation and Angiogenesis by Regulating β-Catenin Expression. Cell Physiol Biochem. 2015;37(6):2194–2208. DOI: 10.1159/000438576. Epub 2015 Nov 27. PMID: 26610149Li J, Zhang Y, Zhao Q, Wang J, He X. MicroRNA-10a Influences Osteoblast Differentiation and Angiogenesis by Regulating β-Catenin Expression. Cell Physiol Biochem. 2015;37(6):2194–2208. DOI: 10.1159/000438576. Epub 2015 Nov 27. PMID: 26610149Zhu S, Deng S, Ma Q, Zhang T, Jia C, Zhuo D, et al. MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2. Circ Res. 2013 Jan 4;112(1):152–164. DOI: 10.1161/CIRCRESAHA.112.280016. Epub 2012 Oct 16. PMID: 23072816; PMCID: PMC3719009Zhu S, Deng S, Ma Q, Zhang T, Jia C, Zhuo D, et al. MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2. Circ Res. 2013 Jan 4;112(1):152–164. DOI: 10.1161/CIRCRESAHA.112.280016. Epub 2012 Oct 16. PMID: 23072816; PMCID: PMC3719009Grundmann S, Hans FP, Kinniry S, Heinke J, Helbing T, Bluhm F, et al. MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells. Circulation. 2011 Mar 8;123(9):999–1009. DOI: 10.1161/CIRCULATIONAHA.110.000323. Epub 2011 Feb 21. PMID: 21339483Grundmann S, Hans FP, Kinniry S, Heinke J, Helbing T, Bluhm F, et al. MicroRNA-100 regulates neovascularization by suppression of mammalian target of rapamycin in endothelial and vascular smooth muscle cells. Circulation. 2011 Mar 8;123(9):999–1009. DOI: 10.1161/CIRCULATIONAHA.110.000323. Epub 2011 Feb 21. PMID: 21339483Zhou Q, Gallagher R, Ufret-Vincenty R, Li X, Olson EN, Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci USA. 2011 May 17;108(20):8287–8292. DOI: 10.1073/pnas.1105254108. Epub 2011 May 2. PMID: 21536891; PMCID: PMC3100947Zhou Q, Gallagher R, Ufret-Vincenty R, Li X, Olson EN, Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc Natl Acad Sci USA. 2011 May 17;108(20):8287–8292. DOI: 10.1073/pnas.1105254108. Epub 2011 May 2. PMID: 21536891; PMCID: PMC3100947

The authors declare that there are no conflicts of interest present.