Возможности биотехнологической платформы тутового шелкопряда (B. mori) для регенеративной медицины

Регенеративная медицина, стремящаяся изменить современную медицинскую практику путем устранения коренных причин болезней и  расстройств, включает генную терапию, клеточную терапию и продукты тканевой инженерии, предназначенные для увеличения, восстановления, замены или регенерации органов, тканей, клеток, генов и метаболических процессов в организме. Биоматериалы — один из ключевых компонентов регенеративной медицины, на которых базируются успешные стратегии.

Представлен обзор биотехнологических методов, применяемых на этапах восходящего (USP) и нисходящего (DSP) процессов с использованием тутового шелкопряда (B. mori), направленных на улучшение качественных характеристик и  получение новых видов биоматериалов для удовлетворения потребностей регенеративной медицины и биомедицины. Разнообразие биотехнологических решений, позволяющих получить широкий спектр биоматериалов: производные оболочки кокона  — фиброин, серицин и  их композиты, рекомбинантные производные, антимикробные пептиды, модифицированные трансгенные шелковые волокна, трансгенные волокна, содержащие факторы роста и пептиды и др., — в совокупности представляет уникальный базис для создания биоиндустриальной платформы на основе тутового шелкопряда.

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