Механизмы участия микроРНК эндотелиальных клеток в регуляции ангиогенеза
https://doi.org/10.60043/2949-5938-2024-2-11-32
Аннотация
XX век ознаменовался пониманием того, что более 80% генов имеют дополнительную биологическую функцию в клетке, связанную с регуляцией экспрессии других генов. С таких генов могут экспрессироваться некодирующие регуляторные РНК различного типа, в том числе и микроРНК, способные изменять экспрессию белков в клетке. МикроРНК представляют собой одноцепочечные последовательности РНК длиной 20–25 нуклеотидов, которые регулируют экспрессию генов на посттранскрипционном уровне посредством деградации или репрессии трансляции целевой мРНК. В настоящем обзоре рассмотрены аспекты биогенеза микроРНК в клетках млекопитающих, а также их функции в эндотелиальных клетках и в регуляции ангиогенеза.
Ключевые слова
При поддержке: Работа выполнена при финансовой поддержке Министерства здравоохранения РФ в рамках научного проекта ГЗ НИР № НИОКТР 124020200013-3 «Некодирующие РНК как перспективное направление в регуляции обновления и репарации сердечно-сосудистой системы».
Об авторах
П. С. Климович
ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»; ФГБУ «Национальный медицинский исследовательский центр кардиологии имени академика Е.И. Чазова» Минздрава России
Россия
Россия
Климович Полина Сергеевна - к.б.н., старший научный сотрудник факультета фундаментальной медицины
119192, г. Москва, Ленинские горы, 1
121552 ул. Академика Чазова, 15а, Москва
В. А. Дзреян
ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»
Россия
Россия
Дзреян Валентина Александровна - к.б.н., научный сотрудник факультета фундаментальной медицины
119192, г. Москва, Ленинские горы, 1
Е. В. Семина
ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»
Россия
Россия
Семина Екатерина Владимировна - д.б.н., ведущий научный сотрудник факультета фундаментальной медицины
119192, г. Москва, Ленинские горы, 1
К. А. Рубина
ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»
Россия
Россия
Рубина Ксения Андреевна - д.б.н., заведующая лабораторией морфогенеза и репарации тканей факультета фундаментальной медицины
119192, г. Москва, Ленинские горы, 1
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Рецензия
Для цитирования:
Климович П.С., Дзреян В.А., Семина Е.В., Рубина К.А. Механизмы участия микроРНК эндотелиальных клеток в регуляции ангиогенеза. Регенерация органов и тканей. 2024;2(2):59-81. https://doi.org/10.60043/2949-5938-2024-2-11-32
For citation:
Klimovich P.S., Dzreyan V.A., Semina E.V., Rubina K.A. Endothelial cells microRNAs participation in the angiogenesis regulation. Регенерация органов и тканей. 2024;2(2):59-81. (In Russ.) https://doi.org/10.60043/2949-5938-2024-2-11-32
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