Notch-сигнальный путь как механизм регуляции остеогенной дифференцировки
https://doi.org/10.60043/2949-5938-2024-4-68-80
Аннотация
Остеогенная дифференцировка — ключевой процесс в формировании и регенерации костной ткани, строго контролируемый различными молекулярными механизмами. Одним из важнейших регуляторов этого процесса является сигнальный путь Notch, способный как подавлять, так и стимулировать остеогенез в зависимости от стадии дифференцировки. В данном обзоре рассматриваются основные этапы остеогенной дифференцировки, роль сигнального пути Notch в регуляции активности клеток костной ткани, а также потенциальные подходы в таргетной модуляции этого пути для терапии заболеваний, сопровождающихся нарушением костного ремоделирования и патологической кальцификацией.
Ключевые слова
остеогенная дифференцировка,
сигнальный путь Notch,
мезенхимные стволовые клетки,
остеобласты,
патологическая кальцификация
При поддержке: Работа выполнена при поддержке гранта Российского научного фонда 23-15-00320.
Об авторах
Д. А. Переплетчикова
ФГБУН «Институт цитологии Российской академии наук»
Россия
Конфликт интересов:
Россия
Переплетчикова Дарья Александровна — м.н.с. Лаборатории регенеративной биомедицины
194064, Санкт-Петербург, Тихорецкий пр-т, 4
Конфликт интересов:
Авторы заявляют об отсутствии конфликта интересов.
Д. В. Смирнова
ФГБУН «Институт цитологии Российской академии наук»
Россия
Конфликт интересов:
Россия
Смирнова Дарья Владимировна — м.н.с. Лаборатории регенеративной биомедицины
194064, Санкт-Петербург, Тихорецкий пр-т, 4
Конфликт интересов:
Авторы заявляют об отсутствии конфликта интересов.
К. Е. Азаркина
ФГБУН «Институт цитологии Российской академии наук»
Россия
Конфликт интересов:
Россия
Азаркина Ксения Евгеньевна — ст. лаб.-исслед. Лаборатории регенеративной биомедицины
194064, Санкт-Петербург, Тихорецкий пр-т, 4
Конфликт интересов:
Авторы заявляют об отсутствии конфликта интересов.
В. А. Семенихин
ООО «Пальмира Биофарма»
Россия
Конфликт интересов:
Россия
Семенихин Вячеслав Алексеевич — гендиректор
119021, Москва, Инновационный центр «Сколково», Большой бульвар 42, стр. 1, офис 136
Конфликт интересов:
Авторы заявляют об отсутствии конфликта интересов.
А. Б. Малашичева
ФГБУН «Институт цитологии Российской академии наук»
Россия
Конфликт интересов:
Россия
Малашичева Анна Борисовна — д.б.н., г.н.с., зав. Лаборатории регенеративной биомедицины
194064, Санкт-Петербург, Тихорецкий пр-т, 4
Конфликт интересов:
Авторы заявляют об отсутствии конфликта интересов.
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Рецензия
Для цитирования:
Переплетчикова Д.А., Смирнова Д.В., Азаркина К.Е., Семенихин В.А., Малашичева А.Б. Notch-сигнальный путь как механизм регуляции остеогенной дифференцировки. Регенерация органов и тканей. 2024;2(4):68-80. https://doi.org/10.60043/2949-5938-2024-4-68-80
For citation:
Perepletchikova D.A., Smirnova D.V., Azarkina K.E., Semenikchin V.A., Malashicheva A.B. The Notch signaling pathway as a mechanism for regulation of osteogenic differentiation. Регенерация органов и тканей. 2024;2(4):68-80. (In Russ.) https://doi.org/10.60043/2949-5938-2024-4-68-80
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