Preview

Регенерация органов и тканей

Advanced search

Epimorphic regeneration of mammalian digit tip

https://doi.org/10.60043/2949-5938-2024-1-46-53

Abstract

The article presents lecture materials on regeneration mechanisms from the textbook “Lectures on Regenerative Medicine”. An example of epimorphic regeneration in mammals is considered — the cellular mechanisms of tissue restoration of the fingertip after amputation. This model is a relevant object of research, since it allows us to study the mechanisms of both the formation of a specialized temporary structure of the blastema and subsequent morphogenesis, which ends with the full restoration of all amputated tissues.

About the Authors

J. G. Antropova
Medical Research and Educational Institute, Lomonosov Moscow State University
Russian Federation

Julia G. Antropova — Ph.D. in Biology, senior research scientist, Laboratory of Gene and Cell Technologies, Biochemistry and Regenerative Medicine Chair, Faculty of Medicine

27-1, Lomonosovsky av., 119192, Moscow



R. Yu. Eremichev
Medical Research and Educational Institute, Lomonosov Moscow State University
Russian Federation

Roman Yu. Eremichev — M.D., Ph.D., junior research scientist, Laboratory of Gene and Cell Therapy, Center of Regenerative Medicine, Medical Scientific and Educational Institute

27-1, Lomonosovsky av., 119192, Moscow



P. I. Makarevich
Medical Research and Educational Institute, Lomonosov Moscow State University
Russian Federation

Pavel I. Makarevich — M.D., D.Sc., Head of the Laboratory of Gene and Cell Therapy, Medical Scientific and Educational Institute

27-1, Lomonosovsky av., 119192, Moscow



N. I. Kalinina
Medical Research and Educational Institute, Lomonosov Moscow State University
Russian Federation

Natalia I. Kalinina — Ph.D. in Biology, leading research scientist, Laboratory of Gene and Cell Technologies, Biochemistry and Regenerative Medicine Chair, Faculty of Medicine

27-1, Lomonosovsky av., 119192, Moscow



References

1. Fernando WA, Leininger E, Simkin J, Li N, Malcom CA, Sathyamoorthi S, et al. Wound healing and blastema formation in regenerating digit tips of adult mice. Dev. Biol. 2011;350:301–310.

2. Simkin J, Han M, Yu L, Yan M, Muneoka K. The mouse digit tip: from wound healing to regeneration. Methods Mol. Biol. 2013;1037:419–435.

3. Takeo M, Chou WC, Sun Q, Lee W, Rabbani P, Loomis C, et al. Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature. 2013;499:228–232.

4. Simkin J, Sammarco MC, Marrero L, Dawson LA, Yan M, Tucker C, et al. Macrophages are required to coordinate mouse digit tip regeneration. Development. 2017;144:3907–3916.

5. Simkin J, Sammarco MC, Dawson LA, Tucker C, Taylor LJ, Van Meter K, Muneoka K. Epidermal closure regulates histolysis during mammalian (Mus) digit regeneration. Regeneration. 2015;2:106–119.

6. Lehoczky JA, Robert B, Tabin CJ. Mouse digit tip regeneration is mediated by fate-restricted progenitor cells. Proc. Natl Acad. Sci. USA. 2011;108(20):609–614.

7. Storer MA, Mahmud N, Karamboulas K, Borrett MJ, Yuzwa SA, Gont A, et al. Acquisition of a unique mesenchymal precursor-like blastema state underlies successful adult mammalian digit tip regeneration. Dev. Cell. 2020;52:1–16.

8. Johnson GL, Masias EJ, Lehoczky JA. Cellular heterogeneity and lineage restriction during mouse digit tip regeneration at single-cell resolution. Dev. Cell. 2020;2:525–540.

9. Dawson LA, Yu L, Yan M, Marrero L, Schanes PP, Dolan C, et al. The periosteal requirement and temporal dynamics of BMP2-induced middle phalanx regeneration in adult mice. Regeneration. 2017;4:140–150.

10. Dawson LA, Schanes PP, Kim P, Imholt FM, Qureshi O, Dolan CP, et al. Blastema formation and periosteal ossification in the regenerating adult mouse digit. Wound Repair Regen. 2018; 26:263–273.

11. Carr MJ, Toma JS, Johnston APW, Steadman PE, Yuzwa SA, Mahmud N, et al. Mesenchymal precursor cells in adult nerves contribute to mammalian tissue repair and regeneration. Cell Stem Cell. 2019;24:240–256.

12. Johnston AP, Yuzwa SA, Carr MJ, Mahmud N, Storer MA, Krause MP, et al. Dedifferentiated Schwann cell precursors secreting paracrine factors are required for regeneration of the mammalian digit tip. Cell Stem Cell. 2016;19:433–448.

13. Rinkevich Y, Montoro DT, Muhonen E, Walmsley GG, Lo D, Hasegawa M, et al. Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration. Proc. Natl Acad. Sci. USA. 2014;111:9846–9851.


Review

For citations:


Antropova J.G., Eremichev R.Yu., Makarevich P.I., Kalinina N.I. Epimorphic regeneration of mammalian digit tip. Регенерация органов и тканей. 2024;2(1):46-53. (In Russ.) https://doi.org/10.60043/2949-5938-2024-1-46-53

Views: 588


ISSN 2949-5938 (Online)